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You should not use Dorzolamide and Timolol drops if you are allergic to dorzolamide (Dorzolamide and Timolol or Trusopt) or timolol (Blocadren, Betimol, Istalol, Timoptic), or if you have:

a history of asthma;
chronic obstructive pulmonary disease (COPD); or
a serious heart condition such as "AV block," slow heartbeats, heart failure, or if you have recently had a heart attack.

To make sure you can safely use Dorzolamide and Timolol drops, tell your doctor if you have any of these other conditions:

narrow-angle glaucoma;
breathing problems such as bronchitis or emphysema;
a history of heart disease or congestive heart failure;
diabetes;
a muscle disorder such as myasthenia gravis;
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FDA pregnancy category C. It is not known whether Cosopt will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Dorzolamide and Timolol drops . It is not known whether Cosopt passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Cosopt. Do not use Cosopt in a child younger than 2 years old.

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