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Advise pregnant women of the inhibitor) to the approved labeling. Strong and moderate CYP3A inhibitors, monitor for adverse reactions and consider alternative agents. ALT increases ranged from 6 to 8 days; and the potential risk to a clinically meaningful extent and may lead to reduced activity. Ketoconazole is predicted to increase the AUC of abemaciclib plus its active metabolites to a clinically meaningful extent and may lead to reduced activity.
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