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Melphalan treats only the symptoms of ovarian cancer or multiple myeloma, but does not treat the cancer itself.

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a weak immune system (caused by disease or by using certain medicine);
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Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using melphalan.

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Call your doctor for instructions if you miss an appointment for your melphalan injection.

What should I avoid while taking melphalan?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

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Do not receive a "live" vaccine while using melphalan. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

melphalan can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Melphalan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

bone marrow suppression--sudden weakness or ill feeling, fever, chills, pale skin, easy bruising or bleeding, red or pink urine, painful mouth sores, cough, trouble breathing, feeling light-headed, rapid heart rate;
inflammation of your blood vessels-numbness or tingling, red skin rash, unusual lumps or masses, fever, weight loss, muscle or joint pain, tired feeling, unusual bleeding; or
liver problems--nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

missed menstrual periods;
weakness; or
temporary hair loss.

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